NEP

NEP (VDP-green (NEP) ) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs) . NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm) . NEP has the potential for parkinsonism[1].

Product Specifications

CAS Number

[2414276-32-5]

Product Name Alternative

VDP-green (NEP)

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nep.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCCC)C2=C3C(C(NC(OCC4S[As](SC4)C5=CC=C(C=C5)NC(CCN)=O)=O)=CC=C3C1=O)=CC=C2

Molecular Formula

C29H31AsN4O5S2

Molecular Weight

654.63

References & Citations

[1]Guodong Hu, et al. Decrease of Protein Vicinal Dithiols in Parkinsonism Disclosed by a Monoarsenical Fluorescent Probe. Anal Chem. 2020 Mar 17;92 (6) :4371-4378.