Losartan (potassium) (Standard)

Losartan (potassium) (Standard) is the analytical standard of Losartan (potassium) . This product is intended for research and analytical applications. Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.

Product Specifications

CAS Number

[124750-99-8]

Product Name Alternative

DuP-753 (potassium) (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/losartan-potassium-standard.html

Purity

99.97

Solubility

DMSO : ≥ 110 mg/mL

Smiles

OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=N[N-]N=N4)C=C2.[K+]

Molecular Formula

C22H22ClKN6O

Molecular Weight

461.00

Precautions

H302, H315, H319, H335

References & Citations

[1]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103 (6) : p. 904-12.|[2]Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.|[3]Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126 (1) : p. 124-31.|[4]Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312 (5770) : p. 117-21.|[5]Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26 (2) : p. 233-40.