JNJ-42153605
JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM.
Product Specifications
CAS Number
[1254977-87-1]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JNJ-42153605.html
Purity
99.24
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
FC(C1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F
Molecular Formula
C22H23F3N4
Molecular Weight
400.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cid JM, et al. Discovery of 3-cyclopropylmethyl-7- (4-phenylpiperidin-1-yl) -8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605) : a positive allosteric modulator of the metabotropic glutamate 2 receptor. J Med Chem. 2012 Oct 25;55 (20) :8770-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2
Available Sizes
Curated Selection
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