JNJ-42153605

JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM.

Product Specifications

CAS Number

[1254977-87-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JNJ-42153605.html

Purity

99.24

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

FC(C1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F

Molecular Formula

C22H23F3N4

Molecular Weight

400.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cid JM, et al. Discovery of 3-cyclopropylmethyl-7- (4-phenylpiperidin-1-yl) -8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605) : a positive allosteric modulator of the metabotropic glutamate 2 receptor. J Med Chem. 2012 Oct 25;55 (20) :8770-89.