M344

M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.

Product Specifications

CAS Number

[251456-60-7]

Product Name Alternative

D 237; MS 344

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/M344.html

Purity

99.76

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1

Molecular Formula

C16H25N3O3

Molecular Weight

307.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Jung M1, et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42 (22) :4669-79.|[2]Weberpals JI, et al. The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11 (1) :29.