M344
M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.
Product Specifications
CAS Number
251456-60-7
Product Name Alternative
D 237; MS 344
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/M344.html
Purity
99.76
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1
Molecular Formula
C16H25N3O3
Molecular Weight
307.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Jung M1, et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42 (22) :4669-79.|[2]Weberpals JI, et al. The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11 (1) :29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC
Available Sizes
Frequently Asked Questions
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