NF-κB-IN-1

NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1].

Product Specifications

CAS Number

[1227098-15-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nf-κb-in-1.html

Concentration

10mM

Purity

98.37

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C(C=C1)=CC(OC)=C1OC)/C(C(/C=C/C(C=C2)=CC(OC)=C2OC)=O)=C/C(C=C3)=CC(OC)=C3O

Molecular Formula

C31H30O8

Molecular Weight

530.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53 (23) :8260-73.