Asenapine (maleate)

Asenapine (Org 5222) maleate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0) . Asenapine maleate can be used in the research of schizophrenia and bipolar disorder[1][2][3][4][5].

Product Specifications

CAS Number

[85650-56-2]

Product Name Alternative

Org 5222 maleate

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H400

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Asenapine-maleate.html

Purity

99.95

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 6.25 mg/mL (ultrasonic; warming)

Smiles

CN1C[C@]2([H])C3=CC=CC=C3OC4=CC=C(Cl)C=C4[C@]2(C1)[H].O=C(O)/C=C\C(O)=O

Molecular Formula

C21H20ClNO5

Molecular Weight

401.84

Precautions

H301, H315, H319, H335, H400

References & Citations

[1]Stoner SC, et al. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34 (5) :1023-40.|[2]Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23 (1) :65-73.|[3]Ohyama M, et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28 (6) :327-336.|[4]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl) . 2008 Feb;196 (3) :417-29.|[5]Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28 (2) :85-91.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

5-HT1 Receptor; MUC3; α-1 microglobulin

Citation 01

Biomed Pharmacother. 2025 Jan:182:117756.|Biomed Pharmacother. 2025 Jan:182:117756.|Insect Biochem Mol Biol. 2025 May:180:104312.|Int J Biol Macromol. 2023 Aug 30:247:125703.