Ophiobolin B

Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement[1]. The MIC values with the antifungal effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL[2].

Product Specifications

CAS Number

[5601-74-1]

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ophiobolin-b.html

Purity

99.53

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12C[C@@]([C@@]3([H])/C(C=O)=C\C[C@@]1([H])[C@](CC2)([C@@H](C)CC/C=C(C)\C)O)([C@](C)(O)CC3=O)[H]

Molecular Formula

C25H38O4

Molecular Weight

402.57

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Gianani L, et al. Effects of ophiobolin B on cell enlargement and H (+) /K (+) exchange in maize coleoptile tissues. Planta. 1979 Jan;146 (3) :271-4.|[2]Krizsán K, et al. Effect of the sesterterpene-type metabolites, ophiobolins A and B, on zygomycetes fungi. FEMS Microbiol Lett. 2010 Dec;313 (2) :135-40.