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Ki11502

Product Specifications

UNSPSC Description

Ki11502 is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGF β/α receptors with IC50 values less than 10 nM. Ki11502 selectively inhibits PDGF β receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Ki11502 can induce Apoptosis) and exhibits profound antiproliferative effects on select subsets of leukemia, including those with Imatinib (HY-15463) resistant mutations. Ki11502 is highly suitable for studying the role of PDGF in vascular diseases, particularly the role of proteoglycans in atherosclerosis[1][2].

Target Antigen

Akt; Apoptosis; Bcl-2 Family; FLT3; PDGFR; PERK

Type

Reference compound

Related Pathways

Apoptosis;Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ki11502.html

Purity

99.30

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(NC(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C=C1)=S)C4=CC=CC=C4C

Molecular Weight

473.54

References & Citations

[1]Getachew R, et al. Characterisation of Ki11502 as a potent inhibitor of PDGF beta receptor-mediated proteoglycan synthesis in vascular smooth muscle cells. Eur J Pharmacol. 2010;626(2-3):186-192.|[2]Nishioka C, et al. Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. Blood. 2008 May 15;111(10):5086-92.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-112417/Ki11502-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-112417/Ki11502-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

347155-76-4

Available Sizes

Curated Selection

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