Bobcat339
Product Specifications
UNSPSC Description
Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
Target Antigen
DNA Methyltransferase; TET Protein
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bobcat339.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O
Molecular Weight
297.74
References & Citations
[1]Chua GNL, et, al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31; 10(2): 180-185.Aquaculture. 2023: 739234.|Br J Pharmacol. 2024 Jun 16.|Brain Sci. 2023 Apr 10, 13(4), 644.|Eur J Pharmacol. 2024 Aug 23:176931.|Research Square Print. 2023 Mar 14.|Research Square Print. November 29th, 2022.|Bioelectrochemistry. 2023 Apr 4;152:108433.|Cancers (Basel). 2022 Jun 16;14(12):2983.|Cell Death Dis. 2024 Jun 1;15(6):387.|Clin Epigenetics. 2024 Oct 2;16(1):136.|Clin Sci. 2023 Aug 31;137(16):1265-1283.|Environ Sci Technol. 2021 Feb 11.|J Clin Invest. 2023 Aug 29;e170173.|J Pharm Biomed Anal. 2021 Jun 24;203:114228.|Mol Pain. 2022 Apr;18:17448069221143671.|Neuropharmacology. 2023 Nov 24:109799.|Sci Total Environ. 2024 Apr 1:919:170905.|Theranostics. 2021 Jun 11;11(16):7640-7657.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111558/Bobcat339-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111558/Bobcat339-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2280037-51-4
Available Sizes
Curated Selection
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