Arbutamine

Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent [1][2][3].

Product Specifications

CAS Number

[128470-16-6]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/arbutamine.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC1=CC=C([C@@H](O)CNCCCCC2=CC=C(O)C=C2)C=C1O

Molecular Formula

C18H23NO4

Molecular Weight

317.38

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m) Tc-sestamibi versus (201) Tl. J Nucl Med. 2002 May;43 (5) :664-70.|[2]Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10 (1) :31-8.|[3]Abou-Mohamed G, et, al. Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing. Cardiovasc Drugs Ther. 1996 Mar;10 (1) :39-47.