Pimethixene maleate
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
Product Specifications
CAS Number
[13187-06-9]
Product Name Alternative
Pimetixene maleate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/pimethixene-maleate.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3.OC(/C=C\C(O)=O)=O
Molecular Formula
C23H23NO4S
Molecular Weight
409.50
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor;5-HT2 Receptor; H1 Receptor; mLAG-3; α-1 microglobulin
Available Sizes
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