Estromustine

Estromustine (EoM) is the active metabolite of Estramustine phosphate (HY-13627A) . Estromustine binds to mutant androgen receptor (m-AR) with EC50 of 2.6 μM in LNCaP, exhibits cytotoxicity in human prostate cells LNCaP with IC50 of 9.73 μM[1].

Product Specifications

CAS Number

[62899-40-5]

Product Name Alternative

EoM

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/estromustine.html

Smiles

C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC(N(CCCl)CCCl)=O)C=C4CC3

Molecular Formula

C23H29Cl2NO3

Molecular Weight

438.39

Precautions

P261-P280-P302+P352

References & Citations

[1]Wang LG, et al., Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55 (9) :1427-33.