PROTAC ERα Degrader-4
PROTAC ERα Degrader-4 (Compound ZD12) is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM) . PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
Product Specifications
CAS Number
2521299-80-7
UNSPSC
12352005
Target
Apoptosis; Estrogen Receptor/ERR; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-erα-degrader-4.html
Purity
99.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C55H62F3N5O10S2
Molecular Weight
1074.23
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
Available Sizes
Frequently Asked Questions
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