HODHBt

HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].

Product Specifications

CAS Number

[28230-32-2]

Product Name Alternative

HOOBt

UNSPSC

12352005

Hazard Statement

H226, H303, H312+H332, H315, H319, H335, H360

Target

HIV; STAT

Type

Reference compound

Related Pathways

Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/hodhbt.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(O)N=NC2=CC=CC=C12

Molecular Formula

C7H5N3O2

Molecular Weight

163.14

Precautions

H226, H303, H312+H332, H315, H319, H335, H360

References & Citations

[1]Macedo AB, et al. The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation. J Virol. 2022 Aug 10;96 (15) :e0037222.