Impurity B of Calcitriol

Impurity B of Calcitriol, Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR) . IC50 value: Target: vitamin D receptor Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol) exhibits antitumor activity; Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Product Specifications

CAS Number

[66791-71-7]

Product Name Alternative

1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/impurity-b-of-calcitriol.html

Purity

98.04

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@@H](C[C@@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@]3([H])[C@@H](CCCC(C)(O)C)C)([H])[C@]3(C)CCC\2

Molecular Formula

C27H44O3

Molecular Weight

416.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) |[2]Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.|[3]Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.|[4]Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.