WNK1 (181-507), Active, GST-tagged Human

<strong>WNK1 (181-507), Active, GST-tagged Human</strong>_x000D_ <strong>Catalog number:</strong> B2019683_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> ~67 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −70°C_x000D_ <strong>Keywords:</strong> HSAN2, HSN2, KDP, KIAA0344, MGC163339, MGC163341, PRKWNK1, PSK, p65_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Xie J, Yoon J, Yang SS, Lin SH, Huang CL. WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade J Biol Chem. 2013 Mar 22;288(12):8566-8574._x000D_ 2: Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD. The single-cell transcriptomic landscape of early human diabetic nephropathy Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625._x000D_ 3: Bahena-Lopez JP, Gamba G, Castañeda-Bueno M. WNK1 in the kidney Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):471-478._x000D_ 4: Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. WNK kinases sense molecular crowding and rescue cell volume via phase separation Cell. 2022 Nov 23;185(24):4488-4506.e20._x000D_ 5: Quelquejay H, Al-Rifai R, Silvestro M, Vandestienne M, Ferreira I, Mirault T, Henrion D, Zhong X, Santos-Zas I, Goudot G, Alayrac P, Robidel E, Autret G, Balvay D, Taleb S, Tedgui A, Boulanger CM, Zernecke A, Saliba AE, Hadchouel J, Ramkhelawon B, Cochain C, Bergaya S, Jeunemaitre X, Ait-Oufella H. L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift Circ Res. 2024 Aug 2;135(4):488-502._x000D_ 6: Li L, Xie D, Yu S, Ma M, Fan K, Chen J, Xiu M, Xie K, Li Y, Gao Y. WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma Cancer Res. 2024 Sep 4;84(17):2776-2791._x000D_ 7: Jung JU, Cobb MH. WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2300310120._x000D_ 8: Ferdaus MZ, Terker AS, Koumangoye RB, Al-Qusairi L, Welling PA, Delpire E. Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance Am J Physiol Renal Physiol. 2024 Sep 1;327(3):F373-F385._x000D_ 9: Bakouh N, Castaño-Martín R, Metais A, Dan EL, Balducci E, Chhuon C, Lepicka J, Barcia G, Losito E, Lourdel S, Planelles G, Muresan RC, Moca VV, Kaminska A, Bourgeois M, Chemaly N, Rguez Y, Auvin S, Huberfeld G, Varlet P, Asnafi V, Guerrera IC, Kabashi E, Nabbout R, Ciura S, Blauwblomme T. Chloride deregulation and GABA depolarization in MTOR related malformations of cortical development Brain. 2024 Aug 6:awae262._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/38269409">10: Bahena-Lopez JP, Vergara L, de la-Peña V, Gutierrez-Gallardo MA, López-Ibargüen P, García JA, Contreras-Carbajal H, Vázquez N, Rincón-Heredia R, Masso F, Bobadilla NA, Castañeda-Bueno M, Ellison DH, Gamba G, Chávez-Canales M. KS-WNK1 is required for the renal response to extreme changes in potassium intake Am J Physiol Renal Physiol. 2024 Mar 1;326(3):F460-F476. </a>_x000D_ _x000D_ <strong>Products Related to WNK1 (181-507), Active, GST-tagged Human can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>