Tubulin polymerization-IN-69

Tubulin polymerization-IN-69 (compund 6c) significantly inhibits microtubule/tubulin polymerization in vitro (78.3% inhibition) with an IC50 value of 6.53 μM, and rapidly induces apoptotic cell death and G2/M cell cycle arrest in MCF-7 cells[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-69.html

Smiles

O=C(C1=C2C=CC=C1)N(CC3=CN(CCC(NC4=CC=C(S(=O)(NC5=NC=CC=C5)=O)C=C4)=O)N=N3)C2=O

Molecular Formula

C25H21N7O5S

Molecular Weight

531.54

References & Citations

[1]Aljuhani A, et al. Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation. Bioorg Chem. 2024 Dec;153:107827.