SARS-CoV S RBD (sf9, Fc)

The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. S protein orchestrates viral entry by attaching the virion to the cell membrane through interactions with human ACE2 and CLEC4M/DC-SIGNR receptors. S protein also impairs target cell killing, cytokine production and down-regulates host tetherin (BST2), countering the antiviral activity of host. SARS-CoV S Protein RBD (sf9, Fc) is the recombinant Virus-derived SARS-CoV S protein RBD, expressed by Sf9 insect cells , with C-rFc labeled tag.

Product Specifications

Product Name Alternative

SARS-CoV S Protein RBD (sf9, Fc), Virus, Sf9 insect cells

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/sars-cov-s-protein-rbd-sf9-fc.html

Molecular Formula

/ (Gene_ID) AAX16192 (R306-F527) (Accession)

Molecular Weight

Approximately 78.9&54.3 kDa

References & Citations

[1]Onnis A, et al. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly. J Exp Med. 2023 Feb 6;220 (2) :e20220906.|[2]Hu B, et al. Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2. Emerg Microbes Infect. 2022 Dec;11 (1) :2275-2287.