(R) -Sulforaphane

(R) -Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R) -Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R) -Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R) -Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[142825-10-3]

Product Name Alternative

L-Sulforaphane

UNSPSC

12352211

Hazard Statement

H301, H315, H319, H334, H335

Target

Bcl-2 Family; Caspase; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-sulforaphane.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL

Smiles

O=[S@@](CCCCN=C=S)C

Molecular Formula

C6H11NOS2

Molecular Weight

177.29

Precautions

H301, H315, H319, H334, H335

References & Citations

[1]De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27;19 (6) :6975-86.|[2]Abdull Razis AF, et al. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128 (12) :2775-82.|[3]Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000;60 (5) :1426-1433.|[4]Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36 (1) :53-64. doi: 10.3892/ijmm.2015.2199. Epub 2015 Apr 28. |[5]Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91 (8) :3147-50.|[6]Chen X, et al. Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of PancreaticCancer via AMPK Dependent Signaling. ell Physiol Biochem. 2018;50 (3) :1201-1215.|[7]Licznerska B, et al. R-sulforaphane modulates the expression profile of AhR, ERα, Nrf2, NQO1, and GSTP in human breast cell lines. Mol Cell Biochem. 2021;476 (2) :525-533.