HDAC6-IN-42
HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor (IC50=0.009 μM). HDAC6-IN-42 shows significant anti-leukemia activity and synergistic effect with Decitabine. HDAC6-IN-42 can be used for the AML research[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-42.html
Solubility
10 mM in DMSO
Smiles
O=C(CN(C1=CC=CC=C1C)C(CC2=C(F)C=C(C(NO)=O)C=C2)=O)NC3CCCCC3
Molecular Formula
C24H28FN3O4
Molecular Weight
441.50
References & Citations
[1]Tretbar M, et al. Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine[J]. European Journal of Medicinal Chemistry, 2024: 116447.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog