WRN inhibitor 7
WRN inhibitor 7 (Compound h6) is a WRN inhibitor. WRN inhibitor 7 effectively inhibits WRN's helicase and ATPase activity (IC50: 9.8 μM and 15.8 μM respectively) . WRN inhibitor 7 can be used for research of microsatellite instable (MSI) cancers[1].
Product Specifications
CAS Number
444780-45-4
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
O=C(N/1)N(CC(NC2=CC=C(C)C=C2)=O)C(C1=C/C3=C(OCC4=CC(C(O)=O)=CC=C4)C=CC=C3)=O
Molecular Formula
C27H23N3O6
Molecular Weight
485.49
References & Citations
[1]Yuan H, et al. Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening. Bioorg Med Chem Lett. 2024 May 15;104:129711.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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