Heteropodatoxin-1
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8[1].
Product Specifications
Product Name Alternative
HpTx1
UNSPSC
12352209
Target
Potassium Channel; Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/heteropodatoxin-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H]3CCCCN)=O)=O)=O)=O)NC4=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@H]9CC(C)C)=O)=O)=O)=O)NC3=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N)=O)=O)=O)=O)=O)=O)=O)NC9=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Molecular Formula
C168H238N46O51S6
Molecular Weight
3910.35
References & Citations
[1]Xi Zhou, et al. Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels. Nat Commun. 2020 May 8;11 (1) :2293.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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