Ammonium iron (III) citrate
Ammonium iron (III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron (III) citrate can enhance protein production[2].
Product Specifications
CAS Number
[1185-57-5]
Product Name Alternative
Ammonium ferric citrate; FAC
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ammonium-iron-iii-citrate.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
OC(CC(C(O)=O)(O)CC(O)=O)=O.[xFe(III)].[xNH3]
Molecular Formula
C6H8O7.xFe.xH3N
Precautions
H302, H315, H319, H335
References & Citations
[1]Yu-Cheng Lai, et al. Towards protein production and application by using Chlorella species as circular economy. Bioresour Technol. 2019 Oct;289:121625.|[2]Shenglin Fang, et al. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018 Sep 3;503 (1) :297-303.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Badge
Hot
Scientific Category
Natural Products
Clinical Information
Launched
Citation 01
Adv Sci (Weinh) . 2025 May 21:e2505359.|Adv Sci (Weinh) . 2025 Nov 6:e07384.|Adv Sci (Weinh) . 2025 Nov 7:e18323.|Bioengineered. 2021 Dec;12 (2) :11610-11621.|Biol Trace Elem Res. 2024 Feb;202 (2) :701-712.|Biol Trace Elem Res. 2025 Jun 13.|Biomed Pharmacother. 2023 Oct:166:115333.|bioRxiv. 2025 Jul 24:2025.07.24.666650.|Drug Des Devel Ther. 2024 Feb 1:18:259-275.|Front Immunol. 2024 Oct 1:15:1397727.|Front Mol Biosci. 2022 Jul 22:9:952608.|Int J Biol Sci. 2024 Aug 6;20 (11) :4222-4237.|J Biochem Mol Toxicol. 2025 Oct;39 (10) :e70484.|mBio. 2025 Mar 24:e0012725.|Oxid Med Cell Longev. 2022 Apr 25;2022:3846217.|Phytomedicine. 2025 Apr 5:141:156702.|Res Sq. 2025 Aug 08.|Research Square Preprint. 2021 Jul.|Food Chem. 2023 Mar 30;405 (Pt A) :134807.|Food Chem. 2025 May 31:489:144992.|J Sep Sci. 2025 Nov;48 (11) :e70312.|Mol Cancer. 2025 Oct 2;24 (1) :238.|Nature. 2025 Jul;643 (8070) :192-200.|New J Chem. 03 Aug 2022.
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