VH032 analogue-2

VH032 analogue-2 is a VH032 (HY-120217) analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH032 analogue-2 will remove the protective group under acidic conditions, and can be directly used for the synthesis of PROTAC molecules. VH032 analogue-2 is a key intermediate for the synthesis of PROTACs based on VHL ligands.

Product Specifications

CAS Number

[1448189-66-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vh032-analogue-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)C)NC(OC(C)(C)C)=O)=O)C[C@H](O)C3

Molecular Formula

C26H36N4O5S

Molecular Weight

516.65

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-47959C 0.1 mL

Mouse Monoclonal CD45RB Antibody (PTPRC/1147) [DyLight 650]

Ask

View Details

HY-RS08652 1 Set

MRGPRX4 Human Pre-designed siRNA Set A

Ask

View Details

MBS8555951-01 0.1 mL

MME (N-Term) Rabbit pAb

Ask

View Details

MBS8555951-02 0.1 mL (AF405L)

MME (N-Term) Rabbit pAb

Ask

View Details

MBS8555951-03 0.1 mL (AF405S)

MME (N-Term) Rabbit pAb

Ask

View Details

MBS8555951-04 0.1 mL (AF610)

MME (N-Term) Rabbit pAb

Ask

View Details