A3AR antagonist 4

A3AR antagonist 4 (Compd 1) is an A3AR antagonist, with Ki values of 30.8 nM (hA3) and 203 nM (hA1), repectively. A3AR antagonist 4 (Compd 1) can be used for the study of cerebral ischemia[1].

Product Specifications

CAS Number

[109740-09-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a3ar-antagonist-4.html

Purity

99.98

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C=CC=C2)C3=CN(C4=CC=CC=C4)N=C13

Molecular Formula

C16H11N3O

Molecular Weight

261.28

Precautions

H302, H315, H320, H335

References & Citations

[1]Vittoria Colotta, et al. New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. J Med Chem. 2007 Aug 23;50 (17) :4061-74.