S-methyl-KE-298

S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

Product Specifications

CAS Number

[143584-75-2]

Product Name Alternative

M-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Metabolite; MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/S-methyl-KE-298.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CSCC(C(O)=O)CC(C1=CC=C(C)C=C1)=O

Molecular Formula

C13H16O3S

Molecular Weight

252.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yoshida H, et al. Identification of metabolites of KE-298, a new antirheumatic drug, and its physiological properties in rats. Biol Pharm Bull. 1996 Mar;19 (3) :424-9.|[2]Endo H, et al. Stereoselectivity and species difference in plasma protein binding of KE-298 and its metabolites. Biol Pharm Bull. 2001 Jul;24 (7) :800-5.|[3]Honda S, et al. Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells. Clin Exp Immunol. 2001 Oct;126 (1) :131-6.