Polyclonal Tbr1 Antibody, Rabbit IgG

The neuronspecific transcription factor Tbox brain 1 (Tbr1) is a transcription factor that is highly expressed in glutamatergic earlyborn cortical neurons, and is specifically expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb. Tbr1 is thought to play an important role in neuronal migration and axonal projection during cortical development. Tbr1/ mice have been characterized by neonatal lethality, severe defects in the axonal projections of the cerebral cortex and impairment of neuronal migration of the cerebral cortex and amygdala.<br> Huang TN, et al. Nat Neurosci. 2014;17(2):2407. doi: 10.1038/nn.3626.<br> Hevner RF, et al. Neuron. 2001;29(2):35366. doi: 10.1016/s08966273(01)002112.<br> General Notes: FOR RESEARCH USE ONLY.