GA32
GA32 (compound 58r) is potent androgen receptor (AR) /glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide (HY-70002) resistance castration-resistant prostate cancer both in vitro and in vivo[1].
Product Specifications
CAS Number
[1386811-71-7]
UNSPSC
12352005
Target
Androgen Receptor; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ga32.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(NC(C2=CC=CC(S(=O)(N3C4=C(CCC3)C=CC=C4)=O)=C2)=O)C=C1
Molecular Formula
C23H19N3O3S
Molecular Weight
417.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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DENTT (aa2-13) (CASK-interacting nucleosome assembly protein, CDA1, Cell division autoantigen 1, CINAP, CTCL, CTCL tumor antigen se20-4, CTCL-associated antigen se20-4, Cutaneous T-cell lymphoma-associated antigen se20-4, Cutaneous T-cell lymphoma-associated tumor antigen se20-4, TSPYL2, Differentially expressed nucleolar TGF-beta1 target, Differentially-expressed nucleolar TGF-beta1 target protein, HRIHFB2216, NP79, Nuclear protein of 79kD, SE204, Testis-specific protein Y encoded-like 2, Testis-specific Y-encoded-like protein 2, TSPX, TSPY-like 2, TSPY-like protein 2)