RP-64477

RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) .

Product Specifications

CAS Number

[135239-65-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/RP-64477.html

Purity

99.62

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

O=C(NCCCC)C1=CC=C(SC)C(NC(C2=CC=C(OCCCCCCCCCC)C=C2)=O)=C1

Molecular Formula

C29H42N2O3S

Molecular Weight

498.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Bello AA, et al. RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51 (4) :413-21.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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