STAT3-SH2 domain inhibitor 1
STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer[1].
Product Specifications
CAS Number
[2816059-41-1]
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-sh2-domain-inhibitor-1.html
Purity
98.58
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(N(C1=CC=C(B(O)O)C=C1)CC2=CC=C(C3CCCCC3)C=C2)CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O
Molecular Formula
C28H28BF5N2O5S
Molecular Weight
610.40
References & Citations
[1]Deng L, et, al. Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3. J Med Chem. 2022 Oct 13;65 (19) :13094-13111.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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