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STAT3-SH2 domain inhibitor 1

Product Specifications

UNSPSC Description

STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer[1].

Target Antigen

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stat3-sh2-domain-inhibitor-1.html

Solubility

DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 80°C)

Smiles

O=C(N(C1=CC=C(B(O)O)C=C1)CC2=CC=C(C3CCCCC3)C=C2)CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O

Molecular Weight

610.40

References & Citations

[1]Deng L, et, al. Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3. J Med Chem. 2022 Oct 13;65(19):13094-13111.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-151577/STAT3-SH2-domain-inhibitor-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-151577/STAT3-SH2-domain-inhibitor-1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2816059-41-1

Available Sizes

Curated Selection

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