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LPPM-8

LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs) . LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a) . LPPM-8 can be used for studying Med25 and Mediator complex biology[1].

Product Specifications

UNSPSC

12352209

Target

ATF6

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lppm-8.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCC[C@H]([C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(C)C)C(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)O

Molecular Formula

C50H89N7O14

Molecular Weight

1012.28

References & Citations

[1]Pattelli ON, et al. A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts Med25 Protein-Protein Interactions. Angew Chem Int Ed Engl. 2024 Mar 25:e202400781.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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