LPPM-8
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs) . LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a) . LPPM-8 can be used for studying Med25 and Mediator complex biology[1].
Product Specifications
UNSPSC
12352209
Target
ATF6
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/lppm-8.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCC[C@H]([C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(C)C)C(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)O
Molecular Formula
C50H89N7O14
Molecular Weight
1012.28
References & Citations
[1]Pattelli ON, et al. A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts Med25 Protein-Protein Interactions. Angew Chem Int Ed Engl. 2024 Mar 25:e202400781.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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