Globotriaosylsphingosine
Product Specifications
UNSPSC Description
Globotriaosylsphingosine (lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research[1].
Target Antigen
Calcium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/globotriaosylsphingosine.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@@H](O[C@H]([C@@H]([C@H]1O)O)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC)CO)[C@@H]1O[C@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO
Molecular Weight
785.91
References & Citations
[1]Choi JY, et al. Lyso-globotriaosylceramide downregulates KCa3.1 channel expression to inhibit collagen synthesis in fibroblasts. Biochem Biophys Res Commun. 2015 Dec 25;468(4):883-8.|[2]Auray-Blais C, et al. How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? Clin Chim Acta. 2010 Dec 14;411(23-24):1906-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N12408/Globotriaosylsphingosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N12408/Globotriaosylsphingosine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
126550-86-5
Available Sizes
Curated Selection
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