Globotriaosylsphingosine

Globotriaosylsphingosine (Lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research[1].

Product Specifications

CAS Number

[126550-86-5]

Product Name Alternative

Lyso-Gb3; Lyso-GL3

UNSPSC

12352005

Target

Calcium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/globotriaosylsphingosine.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@@H](O[C@H]([C@@H]([C@H]1O)O)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC)CO)[C@@H]1O[C@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO

Molecular Formula

C36H67NO17

Molecular Weight

785.91

References & Citations

[1]Choi JY, et al. Lyso-globotriaosylceramide downregulates KCa3.1 channel expression to inhibit collagen synthesis in fibroblasts. Biochem Biophys Res Commun. 2015 Dec 25;468 (4) :883-8.|[2]Auray-Blais C, et al. How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? Clin Chim Acta. 2010 Dec 14;411 (23-24) :1906-14.