Ki67 Monoclonal Antibody

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable) .

MIB; MKI; marker of proliferation Ki; Proliferation marker protein Ki; Antigen identified by monoclonal antibody Ki; PPP1R; MKI67; KIA; MIB-; MIB-1; PPP1R105; marker of proliferation Ki-67; Ki67; Antigen identified by monoclonal antibody Ki-67; Antigen Ki67; Antigen KI-67; Proliferation marker protein Ki-67; Antigen identified by monoclonal Ki 67; Antigen identified by monoclonal Ki-67; MIB 1; Proliferation related Ki 67 antigen; Protein phosphatase 1 regulatory subunit 105; RP11-380J17.2