Safinamide (mesylate)
Safinamide (FCE 26743; EMD 1195686) mesylate is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 nM) [1]. Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 μM) than at resting (IC50=262 μM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al[2][3].
Product Specifications
CAS Number
202825-46-5
Product Name Alternative
FCE 26743 (mesylate) ; EMD 1195686 (mesylate)
UNSPSC
12352005
Hazard Statement
H301, H318, H400
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/safinamide-mesylate.html
Purity
99.07
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 20 mg/mL
Smiles
C[C@H](NCC1=CC=C(OCC2=CC=CC(F)=C2)C=C1)C(N)=O.CS(=O)(O)=O
Molecular Formula
C18H23FN2O5S
Molecular Weight
398.45
Precautions
H301, H318, H400
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAO-A; MAO-B
Citation 01
Behav Brain Res. 2024 Feb 29:459:114787.|Ecotoxicol Environ Saf. 2023 Aug 7:262:115284.
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