P516-0475
P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2].
Product Specifications
CAS Number
1359627-33-0
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/p516-0475.html
Smiles
O=C(C1=C2N(N=N1)C3=C(C=C(C)C=C3)NC2=O)NCCCOC
Molecular Formula
C15H17N5O3
Molecular Weight
315.33
References & Citations
[1]Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293 (3) : 931-940.|[2]Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11 (4) :e0527922.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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