Pyridoxal phosphate

Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

Product Specifications

CAS Number

[54-47-7]

Product Name Alternative

Pyridoxal 5′-phosphate; Pyridoxyl phosphate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Endogenous Metabolite; ERK; Reverse Transcriptase

Type

Natural Products

Related Pathways

Anti-infection; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Pyridoxal_phosphate.html

Purity

99.95

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic)

Smiles

O=CC1=C(O)C(C)=NC=C1COP(O)(O)=O

Molecular Formula

C8H10NO6P

Molecular Weight

247.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71 (1) :180-7.|[2]Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394 (1) :100-5.|[3]Zhang P, et al., High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c‑Jun pathway. Mol Med Rep. 2013 Oct;8 (4) :973-8.|[4]Choi JM, et al., Membrane-Free Stem Cells and Pyridoxal 5'-Phosphate Synergistically Enhance Cognitive Function in Alzheimer's Disease Mouse Model. Antioxidants (Basel) . 2022 Mar 21;11 (3) :601.|[5]Zhang L, et al., Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer. Cell Death Dis. 2017 Dec 13;8 (12) :3214.|[6]Nakamura S, et al., Pyridoxal phosphate prevents progression of diabetic nephropathy. Nephrol Dial Transplant. 2007 Aug;22 (8) :2165-74.