KTX-582 intermediate-2

KTX-582 intermediate-2 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].

Product Specifications

CAS Number

[2434850-07-2]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

ADC Related

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ktx-582-intermediate-2.html

Purity

96.18

Solubility

10 mM in DMSO

Smiles

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@H]4C[C@@H](C4)OCCCNC)=C3C1=O.Br

Molecular Formula

C21H27BrN4O5

Molecular Weight

495.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2022147465 A1. 2022-07-07.