PAR4 antagonist 3

PAR4 antagonist 3 (Compound 36) is a selective antagonist for protease activated receptor 4 (PAR4) . PAR4 antagonist 3 exhibits antiplatelet efficacy with IC50 of 26.1 nM. PAR4 antagonist 3 improves metabolic stablility in human liver microsomes with T1/2 of 97.6 min[1].

Product Specifications

CAS Number

[3057206-40-0]

UNSPSC

12352005

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/par4-antagonist-3.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(OCC2COC3=CC=C4C(OC(C5=CN6C(SC(OC)=N6)=N5)=C4)=C3O2)C=C1

Molecular Formula

C22H16FN3O5S

Molecular Weight

453.44

References & Citations

[1]Chen P, et al., Discovery of 2,3-Dihydro[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity and Low Bleeding Tendency. J Med Chem. 2024 Apr 11;67 (7) :5502-5537.