ANO1-IN-4

ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum[1].

Product Specifications

CAS Number

[2098490-06-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ano1-in-4.html

Purity

99.18

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(NC(C(F)(Br)F)=O)SC2=C1CCCCC2)NC3=C(C)C=CC=C3

Molecular Formula

C19H19BrF2N2O2S

Molecular Weight

457.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Truong EC, et al., Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A) . J Med Chem. 2017 Jun 8;60 (11) :4626-4635.