Carboxylesterase 2 (Human Highly Pure)

<strong>Carboxylesterase 2 (Human Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010479_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 60 kDa_x000D_ <strong>Supplied as:</strong> Lyophilized powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure (&gt; 95%) human carboxylesterase 2 expressed in HEK 293 cells. This protein has a wide variety of applications in biochemistry and cellular biology._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> CE-2 Protein, CES2A1 Protein, iCE Protein, PCE-2 Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Song SS, Sun CP, Zhou JJ, Chu L. Flavonoids as human carboxylesterase 2_x000D_ inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol_x000D_ Macromol. 2019 Jun 15;131:201-208._x000D_ _x000D_ 2: Zou LW, Jin Q, Wang DD, Qian QK, Hao DC, Ge GB, Yang L. Carboxylesterase_x000D_ Inhibitors: An Update. Curr Med Chem. 2018;25(14):1627-1649._x000D_ _x000D_ 3: Wang Y , Yu F , Luo X , Li M , Zhao L , Yu F . Visualization of_x000D_ carboxylesterase 2 with a near-infrared two-photon fluorescent probe and_x000D_ potential evaluation of its anticancer drug effects in an orthotopic colon_x000D_ carcinoma mice model. Chem Commun (Camb). 2020 Apr 25;56(32):4412-4415._x000D_ _x000D_ 4: Liu X, Li X, Dong P, Wu Z, Gao J, Wang Q. Near-infrared emission tracks_x000D_ inter-individual variability of carboxylesterase-2 via a novel molecular_x000D_ substrate. Mikrochim Acta. 2020 May 6;187(6):313._x000D_ _x000D_ 5: Sun CP, Yang ZJ, Zhao WY, Zhang RY, Li H, Chen LX. A novel 15-spiro_x000D_ diterpenoid dimer from Andrographis paniculata with inhibitory potential against_x000D_ human carboxylesterase 2. Bioorg Chem. 2020 Apr;97:103680._x000D_ _x000D_ 6: Chen F, Zhang B, Parker RB, Laizure SC. Clinical implications of genetic_x000D_ variation in carboxyl_esterase drug metabolism. Expert Opin Drug Metab Toxicol._x000D_ 2018 Feb;14(2):131-142._x000D_ _x000D_ 7: Zhao YS, Qian XK, Guan XQ, Song PF, Song YQ, He RJ, Sun MR, Wang XY, Zou LW,_x000D_ Ge GB. Discovery of natural alkaloids as potent and selective inhibitors against_x000D_ human carboxyl_esterase 2. Bioorg Chem. 2020 Dec;105:104367._x000D_ _x000D_ 8: Liu TT, Huo XK, Tian XG, Liang JH, Yi J, Zhang XY, Zhang S, Feng L, Ning J,_x000D_ Zhang BJ, Sun CP, Ma XC. Demethylbellidifolin isolated from Swertia bimaculate_x000D_ against human carboxylesterase 2: Kinetics and interaction mechanism merged with_x000D_ docking simulations. Bioorg Chem. 2019 Sep;90:103101._x000D_ _x000D_ 9: Tsugoshi Y, Watanabe Y, Tanikawa Y, Inoue C, Sugihara K, Kojima H, Kitamura_x000D_ S. Inhibitory effects of organophosphate esters on carboxylesterase activity of_x000D_ rat liver microsomes. Chem Biol Interact. 2020 Aug 25;327:109148_x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28099843/">10: Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL,_x000D_ Näslund E, Nomura DK, Zierath JR. Human Carboxylesterase 2 Reverses Obesity-_x000D_ Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017 Jan_x000D_ 17;18(3):636-646. </a>_x000D_ _x000D_ <strong>Products Related to Carboxylesterase 2 (Human Highly Pure) </strong> <a href="https://moleculardepot.com/product-category/Enzymes/">: Enzymes</a>