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Barnidipine (hydrochloride)

Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3][4].

Product Specifications

CAS Number

104757-53-1

Product Name Alternative

Mepirodipine (hydrochloride) ; YM-09730-5

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/barnidipine-hydrochloride.html

Purity

99.94

Solubility

DMSO : 233.33 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)O[C@@H]3CN(CC4=CC=CC=C4)CC3.[H]Cl

Molecular Formula

C27H30ClN3O6

Molecular Weight

528.00

Precautions

H317, H319

References & Citations

[1]van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8.|[2]Malhotra HS, et al. Barnidipine. Drugs. 2001;61 (7) :989-96; discussion 997-8.|[3]Teramura T, et al. Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human. Xenobiotica. 1995 Nov;25 (11) :1237-46.|[4]Hashimoto M, et al. Treatment with a Ca (2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19 (5) :615-21.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

L-type calcium channel

Available Sizes

Frequently Asked Questions

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