C-Reactive Protein (CRP) (174-185)

C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma[1][5].

Product Specifications

CAS Number

[147516-85-6]

UNSPSC

12352209

Target

Akt; Caspase; mTOR

Type

Peptides

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/c-reactive-protein-crp-174-185.html

Purity

99.88

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@H]1N(C([C@H](CO)NC([C@H](CC2=CC=CC=C2)NC([C@H]3N(C(CNC(CNC([C@H](CC(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H]([C@@H](C)CC)N)=O)=O)=O)=O)=O)CCC3)=O)=O)=O)CCC1)=O)=O)=O

Molecular Formula

C62H93N13O16

Molecular Weight

1276.48

References & Citations

[1]Singh SK, et al. Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection. Front Immunol. 2020 Aug 13;11:1812. |[2]Devaraj S, et al. C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. Atherosclerosis. 2009 Mar;203 (1) :67-74. |[3]Chen JY, et al. C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia. J Transl Med. 2020 Feb 11;18 (1) :68. |[4]Tang Y, et al. C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration. Clin Sci (Lond) . 2014 May;126 (9) :645-59. |[5]Yan X, et al. C-reactive protein promotes tongue squamous cell carcinoma chemoresistance by inhibiting the activation of caspase-3/9 via the CD64/AKT/mTOR pathway. Hum Cell. 2021 Sep;34 (5) :1424-1433. |[6]Ansar W, et al. C-reactive protein and the biology of disease. Immunol Res. 2013 May;56 (1) :131-42.