VPC-18005
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1].
Product Specifications
CAS Number
2242480-48-2
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vpc-18005.html
Purity
99.80
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(O)CC(S/C(N1)=N\N=C/C2=CC=C(C(C)C)C=C2)C1=O
Molecular Formula
C15H17N3O3S
Molecular Weight
319.38
References & Citations
[1]Miriam S Butler, et al. Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget. 2017 Jun 27;8 (26) :42438-42454.|[2]Haneen Amawi, et al. The use of zebrafish model in prostate cancer therapeutic development and discovery. Cancer Chemother Pharmacol. 2021 Mar;87 (3) :311-325.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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