RSK3 (Phospho Thr353) rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by multiple phosphorylations on threonine and serine residues. function: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. PTM: Autophosphorylated on Ser-377, as part of the activation process. similarity: Belongs to the protein kinase superfamily. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 2 protein kinase domains. subunit: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation. tissue specificity: Expressed in many tissues. Highest expression in lung and skeletal muscle.

Product Specifications

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues., function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB., PTM:Autophosphorylated on Ser-377, as part of the activation process., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 2 protein kinase domains., subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation., tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.

UniProt

Q15349

Swiss Prot

Q15349

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human RSK3 (Phospho Thr353)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight

80kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

80kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm .

Other Product Names

Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2; EC 2.7.11.1;90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ribosomal S6 kinase 3; RSK-3; pp90RSK3)