H3K27 (Me) (15-34)

H3K27 (Me) (15-34), a histone peptide, is a repressive chromatin markderived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27 (Me) [1][2].

Product Specifications

UNSPSC

12352209

Target

Histone Methyltransferase

Type

Peptides

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/h3k27-me-15-34.html

Solubility

10 mM in DMSO

Smiles

[H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCNC)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(O)=O

Molecular Formula

C85H152N30O25

Molecular Weight

1994.34

References & Citations

[1]Elizabeth T Wiles, et al. H3K27 Methylation: A Promiscuous Repressive Chromatin Mark. Curr Opin Genet Dev. 2017 Apr;43:31-37.|[2]Brian P Chadwick, et al. Multiple Spatially Distinct Types of Facultative Heterochromatin on the Human Inactive X Chromosome. Proc Natl Acad Sci U S A. 2004 Dec 14;101 (50) :17450-5.